【Chemical Properties】
2,4-Diamino-6-hydroxypyrimidine yog ib qho dawb mus rau lub teeb heev reddish daj crystalline hmoov.
Nws yog alkaline thiab tuaj yeem ua rau cov kua qaub los tsim cov ntsev.
Lub compound muaj cov khoom fluorescent nyob rau hauv lub teeb ultraviolet thiab tuaj yeem tawm daj fluorescence.
Nws cov mis molecular yog C4H6N4O thiab nws qhov hnyav molecular yog 126.12.
Lub melting point yog hais txog 286 degree thiab nws yuav decompose ntawm qhov kub thiab txias.
【Daim ntawv thov】
2,4-Diamino-6-hydroxypyrimidine muaj ntau yam kev siv, feem ntau suav nrog cov hauv qab no:
Tshuaj synthesis: Nws yog ib qho tseem ceeb ntawm qee cov tshuaj tiv thaiv qog thiab tseem siv los tsim cov tshuaj pyrimidine nucleotide.
Kev tshawb fawb biochemical: Raws li cov khoom lag luam nruab nrab ntawm pyrimidine nucleotide metabolism, nws ua lub luag haujlwm tseem ceeb hauv kev tshawb fawb tshuaj thiab biochemistry.
GTP cyclohydrolase I inhibitor: 2,4-Diamino-6-hydroxypyrimidine yog ib qho tshwj xeeb inhibitor ntawm GTP cyclohydrolase I, uas yog tus nqi txwv enzyme hauv de novo synthesis ntawm pterin. Nws inhibits zus tau tej cov NO los ntawm thaiv cov synthesis ntawm tetrahydrobiopterin (BH4).
Organic synthesis: Nws yog siv nyob rau hauv lub tshav pob ntawm cov organic synthesis, nrog rau raws li ib tug intermediate los yog reagent rau cov synthesis ntawm tej tebchaw nyob rau hauv lub laboratory.
Kev kuaj xyuas reagent: 2,4-diamino-6-hydroxypyrimidine yog siv los kuaj xyuas nitrates thiab nitrites.
Pharmaceutical intermediate: Nws yog siv los ua tshuaj nruab nrab los tsim cov tshuaj tshwj xeeb, xws li carboxy-M, antihypertensive tshuaj mitraz, tshuaj tiv thaiv ntshav qab zib folic acid, thiab lwm yam.