Hydroxyproline thiab L-Proline: Cov Cheebtsam txawv nrog cov yam ntxwv tshwj xeeb
1, Taw qhia
L-Proline thiab hydroxyproline yog ob lub tebchaw sib txawv, txhua tus muaj nws cov khoom tshwj xeeb thiab kev ua haujlwm.
2, Qhov sib txawv ntawm cov qauv tshuaj
L-Proline tsis muaj ib pawg hydroxyl txuas nrog gamma carbon atom. Hauv qhov sib piv, hydroxyproline distinguishes nws tus kheej ntawm proline los ntawm muaj ib pawg hydroxyl (OH) txuas rau gamma carbon atom.
3, Khoom thiab Kev Ua Haujlwm ntawm L-Proline
L-Proline yog ib qho tseem ceeb amino acid nyob rau hauv pob txha mos. Nws yog ib qho tseem ceeb rau ntau yam kev ua haujlwm lom neeg xws li tswj cov tawv nqaij hluas thiab ua kom yooj yim kho cov leeg nqaij, cov ntaub so ntswg, thiab cov tawv nqaij puas. Nws tseem yog ib qho tseem ceeb rau lub cev tiv thaiv kab mob thiab tswj xyuas qhov tsim nyog sib npaug ntawm ib qho qauv.
4, Khoom thiab Kev Ua Haujlwm ntawm Hydroxyproline
Hydroxyproline yog ib qho nruab nrab heterocyclic protein amino acid. Nws yog ib tug derivative ntawm proline pom nyob rau hauv lub fibrous connective cov ntaub so ntswg protein hu ua collagen thiab nyob rau hauv ib co nroj tsuag proteins. Yog li ntawd, nws yog qhov tshwm sim hauv ntau cov khoom gelatin.
Hydroxyproline feem ntau yog siv los ua tus cim kev kuaj mob rau cov pob txha hloov pauv thiab daim siab fibrosis. Kev kho mob, nws tau raug kawm raws li kev sim tshuaj thiab tau txais kev pom zoo hauv Fabkis raws li cov khoom siv tshuaj pleev ib ce npe hu ua Cicactive rau cov qhov txhab me me.
Trans-4-hydroxy-L-proline yog ib hom kev kho qhov muag ntawm 4-hydroxyproline nrog L-trans configuration. Nws ua haujlwm raws li tib neeg metabolite, cog metabolite, thiab nas metabolite. Nws yog ib tug tautomer ntawm ib tug trans-4-hydroxy-L-proline zwitterion.
Hydroxyproline yog ib qho metabolite pom hauv lossis tsim los ntawm Escherichia coli (strain K12, MG1655).
Hydroxyproline yog tsim los ntawm hydroxylation ntawm cov amino acid proline los ntawm enzyme prolyl hydroxylase tom qab protein synthesis (raws li kev hloov pauv tom qab). Cov tshuaj tiv thaiv enzyme-catalyzed tshwm sim hauv lumen ntawm endoplasmic reticulum. Txawm hais tias nws tsis ncaj qha mus rau hauv cov proteins, hydroxyproline muaj kwv yees li 4% ntawm tag nrho cov amino acids pom nyob rau hauv cov ntaub so ntswg tsiaj, tus nqi ntau dua li ntawm xya lwm cov amino acids uas tau muab tso rau hauv lub sijhawm txhais lus.
Yog tias koj xav paub ntxiv, thov nyem rau ntawm daim duab saum toj no!