Tributyrin yog ib qho triglyceride uas tau txais los ntawm kev acylation ntawm peb pawg hydroxy ntawm glycerol los ntawm butyric acid. Tributyrin tau pom tias ua haujlwm ua tus inhibitor, tus neeg sawv cev tiv thaiv, apoptosis inducer, prodrug, thiab tus neeg sawv cev antineoplastic. Hauv kev sib piv rau butyrate, tributyrin nthuav tawm cov tshuaj pharmacokinetics zoo dua thiab zam tau zoo. Raws li ib qho ruaj khov thiab sai absorbed prodrug ntawm butyric acid, tributyrin tau pom tias yuav txhim khu kev tiv thaiv cov teebmeem ntawm dihydroxycholecalciferol hauv tib neeg cov kab mob qog noj ntshav.
Tributyrin, prodrug ntawm natural butyrate, tau raug soj ntsuam nrog lub hom phiaj ntawm kev kov yeej cov kev txwv pharmacokinetic ntawm natural butyrate raws li ib tug kws tshuaj. Cov kev txwv no suav nrog nws cov metabolization sai thiab nws tsis muaj peev xwm ua tiav cov tshuaj pharmacological hauv cov hlwb neoplastic. Lub hom phiaj ntawm txoj kev tshawb no yog los tshuaj xyuas qhov cuam tshuam ntawm tributyrin ntawm kev loj hlob, kev sib txawv, thiab cov vitamin D receptor qhia ntawm Caco-2 hlwb, tib neeg txoj hnyuv kab mob qog noj ntshav. Tributyrin pom muaj zog ntau dua hauv inhibiting kev loj hlob thiab inducing cell txawv dua li ntuj butyrate. Tsis tas li ntawd, cov txiaj ntsig tau nce ntxiv tom qab qhov sib ntxiv ntawm physiologic concentrations ntawm dihydroxycholecalciferol.
Tributyrin tuaj yeem siv nws txoj kev loj hlob-txo thiab sib txawv-inducing nyhuv hauv Caco-2 hlwb, tsawg kawg hauv ib feem, los ntawm kev tswj hwm cov vitamin D receptor. Qhov no tuaj yeem muab txoj hauv kev kho tau zoo hauv kev tiv thaiv kab mob thiab kev kho mob qog noj ntshav ntawm lub plab los ntawm ob lub as-ham tshwm sim hauv tib neeg noj.
Nyob rau hauv ib txwm colonic mucosa, butyrate ua haujlwm ua lub zog tseem ceeb, txhawb kev loj hlob ntawm ib txwm colonic epithelial hlwb hauv vivo thiab hauv vitro, thiab ua lub luag haujlwm tiv thaiv qee hom kab mob colitis. Nyob rau hauv sib piv, nyob rau hauv ib tug ntau yam ntawm neoplastic hlwb, butyrate ua raws li ib tug muaj zog antineoplastic tus neeg saib xyuas, inhibiting kev loj hlob thiab inducing sib txawv, li no rov qab ib txwm phenotype thiab muaj nuj nqi.
Txawm hais tias nws tau cog lus thawj zaug, butyrate tsis yog tam sim no ntawm cov tshuaj siv hauv kev kho mob qog noj ntshav.
Tributyrin yog ib qho tshuaj ntawm butyrate. Nws yog ib qho nruab nrab triglyceride uas zoo li yuav kov yeej cov teeb meem ntawm butyrate ua tshuaj. Nws muaj cov tshuaj pharmacokinetics zoo dua thiab muaj kev zam zoo. Muab ntim rau hauv gelatin tsiav tshuaj thiab muab tshuaj rau qhov ncauj, nws ua rau cov millimolar concentrations ntawm butyrate hauv cov ntshav thiab cov hlwb.
Tributyrin siv cov tshuaj tiv thaiv kab mob ntawm cov qog nqaij hlav qog noj ntshav ntau dua li butyrate nws tus kheej.
Tributyrin muaj zog dua butyrate hauv kev txo cov Caco-2 hlwb hauv kab lis kev cai.