Pimobendan (INN, los yog pimobendane), muag raws li lub npe Vetmedin ntawm lwm tus, yog cov tshuaj kho tsiaj. Nws yog calcium sensitizer thiab xaiv inhibitor ntawm phosphodiesterase 3 (PDE3) nrog cov teebmeem inotropic thiab vasodilator zoo.
Pimobendan yog siv los tswj lub plawv tsis ua hauj lwm hauv dev, feem ntau tshwm sim los ntawm myxomatous mitral valve kab mob (tseem hu ua endocardiosis), los yog dilated cardiomyopathy. Kev tshawb fawb tau pom tias raws li kev kho mob monotherapy, pimobendan ua rau lub sijhawm muaj sia nyob thiab txhim kho lub neej zoo hauv cov neeg mob canine nrog lub plawv tsis ua haujlwm thib ob rau cov kab mob mitral valve thaum piv nrog benazepril, ACE inhibitor. Raws li lub npe Acardi, nws muaj rau tib neeg siv hauv Nyij Pooj. Nws muaj raws li cov tshuaj generic.
Pimobendan yog ib hom tshuaj uas feem ntau muab rau cov dev uas muaj qee yam mob plawv. Nws belongs rau ib chav kawm ntawm cov tshuaj hu ua inodilators, uas ib txhij txhim kho lub plawv contractility thiab dilate cov hlab ntsha, yog li pab txhawb cov ntshav khiav.
Kev siv tshuaj kho mob: Pimobendan kho mob plawv tsis ua hauj lwm hauv cov dev uas muaj kab mob myxomatous mitral valve lossis dilated cardiomyopathy. Nws tuaj yeem siv nrog lwm yam kev kho mob plawv. Nws kuj tseem siv los ncua kev mob plawv tsis ua haujlwm hauv cov dev nrog Theem B2 preclinical myxomatous mitral valve kab mob.
Nws ua haujlwm li cas: Pimobendan pab lub plawv dhia zog. Nws ua rau cov leeg nqaij rhiab heev rau calcium. Hauv lub siab ib txwm, nws nce oxygen thiab siv zog ntau npaum li dobutamine ua. Hauv lub siab mob, nws yuav tsis. Pimobendan tseem ua rau cov hlab ntsha hauv lub cev dav dua los ntawm kev txwv tsis pub PDE3 ua haujlwm. Qhov no ua rau nws yooj yim dua rau cov ntshav ntws los ntawm lub cev, uas pab lub plawv ua haujlwm zoo dua thiab txo cov mitral regurgitation.
Abstract. Pimobendan muaj ob lub tswv yim ntawm kev ua: nws nce myocardial contractility los ntawm kev nce calcium rhiab heev rau troponin C thiab nws txhawb vasodilation los ntawm inhibiting PDEIII.
Cov kev mob tshwm sim feem ntau muaj xws li mob plab hnyuv xws li txo qis qab los noj mov, thiab raws plab. Lwm cov kev mob tshwm sim muaj xws li lethargy thiab ua tsis taus pa nyuaj Cov tshuaj noj luv luv no yuav tsum tsis txhob ua haujlwm li ntawm 24 teev, txawm hais tias cov teebmeem tuaj yeem ntev dua rau cov tsiaj uas muaj kab mob siab lossis raum.
Dab tsi yog cov tshuaj zoo tshaj plaws rau tus dev nrog lub plawv yws?
Ib qho inotrope (cov tshuaj uas pab txhawb lub zog ntawm lub plawv thiab txo qis hauv cov hlab ntsha thiab cov hlab ntsha) yuav raug sau tseg. Vetmedin yog cov tshuaj siv ntau tshaj plaws hauv cov tshuaj kho tsiaj. Lwm qhov koj tuaj yeem ua nyob rau theem no yog hloov mus rau cov zaub mov noj dev.