Txoj kev loj hlob ntawm cov organic chemistry txoj kev tshawb fawb tau dhau los ntawm cov txheej txheem los ntawm kev tuav haujlwm mus rau automation thiab computerization, thiab los ntawm tas li mus rau ultra-microscopic nyiaj.
Ua ntej 40s ntawm lub xyoo pua 20th, cov txheej txheem ib txwm siv ntawm distillation, crystallization, sublimation thiab lwm yam kev siv los ntxuav cov khoom, thiab cov qauv txiav txim siab los ntawm cov tshuaj degradation thiab derivative npaj. Tom qab ntawd, daim ntawv thov ntawm ntau yam chromatography thiab electrophoresis cov tswv yim, tshwj xeeb tshaj yog high-pressure kua chromatography, hloov lub ntsej muag ntawm kev sib cais technology. Kev siv ntau yam spectroscopic thiab lub zog spectroscopy cov tswv yim tau ua rau cov organic chemists los kawm txog cov lus tsa suab ntawm cov molecules, uas tau hloov pauv txoj kev txiav txim siab ntawm cov qauv. Kev taw qhia ntawm cov khoos phis tawj hluav taws xob tau ua ib kauj ruam loj rau pem hauv ntej ntawm kev coj ua automation thiab ultra-microquantification ntawm cov organic tebchaw. Nuclear magnetic resonance spectroscopy thiab infrared spectroscopy nrog Fourier transform technology muab txoj kev tshiab rau kev kawm txog cov tshuaj tiv thaiv kinetics thiab cov tshuaj tiv thaiv mechanism. Cov cuab yeej no, ua ke nrog X-ray structural tsom xam thiab electron diffraction spectroscopy, muaj peev xwm txiav txim siab cov qauv tshuaj ntawm microgram kuaj. Qee qhov kev nce qib kuj tau ua nyob rau hauv txoj kev tshawb fawb ntawm kev siv cov tshuab hluav taws xob hauv computer los tsim cov txheej txheem hluavtaws. Nyob rau hauv lub neej yav tom ntej, txoj kev loj hlob ntawm cov organic chemistry yog thawj zaug los kawm txog kev txhim kho thiab kev siv lub zog thiab cov peev txheej. Feem ntau ntawm lub zog thiab cov peev txheej uas peb tau siv los txog tam sim no, xws li thee, natural gas, oil, flora, fauna, and microorganisms, are chemical storage forms of solar energy. Nyob rau hauv lub neej yav tom ntej, qee qhov teeb meem tseem ceeb tshaj plaws nyob rau yav tom ntej yuav yog kev siv lub hnub ci ncaj qha thiab siv tau zoo.
Kev tshawb fawb ntau ntxiv thiab siv tau zoo ntawm photosynthesis yog ib lub ntsiab lus hauv cov nroj tsuag physiology, biochemistry thiab organic chemistry. Organic chemistry tuaj yeem siv cov tshuaj tiv thaiv photochemical los tsim cov khoom siv hluav taws xob siab, khaws cia, thiab siv lawv cov kev cuam tshuam rov qab los tso tawm lub zog thaum tsim nyog. Lwm lub hom phiaj ntawm kev txhim kho cov peev txheej yog kho cov pa roj carbon dioxide hauv cov lus teb rau organometallic tebchaw los tsim cov khoom siv tsis kawg ntawm cov organic tebchaw. Qee cov txiaj ntsig ua ntej tau txais hauv cov kev tshawb fawb no. Qhov thib ob yog kev tshawb fawb thiab kev loj hlob ntawm cov organocatalysts tshiab, uas ua rau lawv ua raws li kev ua haujlwm siab, ua haujlwm tau zoo thiab maj mam tawm tsam hom enzymes. Kev tshawb fawb hauv cheeb tsam no twb tau pib lawm, thiab yuav muaj kev txhim kho ntxiv yav tom ntej. Thaum kawg ntawm lub 60s ntawm lub xyoo pua 20th, lub computer-pab tsim kev tshawb fawb ntawm organic synthesis pib. Nyob rau hauv lub neej yav tom ntej, kev tsim cov txheej txheem ntawm cov organic synthesis thiab kev txiav txim siab ntawm cov qauv ntawm cov organic tebchaw yuav dhau los ua cov txheej txheem thiab cov laj thawj.