Cov khoom siv tshuaj
Sodium triacetoxyborohydride yog dawb crystalline hmoov uas yooj yim soluble nyob rau hauv benzene thiab tetrahydrofuran, soluble nyob rau hauv acetonitrile thiab 1, 2-dichloroethane thiab heev polar organic solvents. Txawm li cas los xij, nws tsis zoo solubility hauv ether cov kuab tshuaj xws li ether, thiab cov compound tuaj yeem hnov mob nrog dej. Yog li ntawd, yuav tsum tau saib xyuas tshwj xeeb thaum khaws cia. Nws yuav tsum tau muab tso rau hauv qhov chaw uas tsis muaj dej tsis muaj dej thiab cov khoom tawg, thiab qhov kub thiab txias yuav tsum tswj tau ntawm -20 degree .
Daim ntawv thov
Sodium triacetoxyborohydride yog cov nyiam catalyst rau reductive amination cov tshuaj tiv thaiv vim nws zoo heev universality thiab selectivity, me me cov tshuaj tiv thaiv, zoo catalytic txo kev ua tau zoo, thiab yooj yim sib cais thiab purification. Cov catalyst nws tus kheej thiab cov khoom los ntawm cov khoom tsis muaj tshuaj lom thiab tsis ua rau ib puag ncig. Tshwj xeeb, nws yog feem ntau siv hauv cov hauv qab no:
1. Reductive amination / lactamization ntawm carbonyl complexes thiab amines: Nyob rau hauv cov kua qaub tsis muaj zog, sodium triacetoxyborohydride tuaj yeem ua rau carbonyl tebchaw nrog amines los tsim imines (Schiff bases), uas yog txo mus rau amines. Cov tshuaj tiv thaiv no muaj cov txiaj ntsig tseem ceeb hauv kev sib xyaw ntawm cov tshuaj molecules thiab derivatization ntawm bioactive molecules.
2. Reductive amination ntawm aromatic aldehydes: Nyob rau hauv tej yam kev mob, sodium triacetoxyborohydride tuaj yeem ua tau zoo hloov cov ntxhiab aldehydes rau hauv cov amine tebchaw, uas yog ib kauj ruam tseem ceeb hauv cov organic synthesis.
3. Kev txo qis: Txawm hais tias sodium triacetoxyborohydride muaj zog txo cov khoom, nyob rau hauv tej yam kev mob, nws muaj peev xwm xaiv kom txo tau tej yam functional pawg, xws li aldehydes, tsis muaj kev cuam tshuam rau lwm cov functional pawg uas muaj nyob rau tib lub sij hawm, xws li ketone carbonyls. Qhov kev xaiv txo cov khoom no ua rau sodium triacetoxyborohydride dav siv hauv cov organic synthesis tshwj xeeb.
Tsis tas li ntawd, sodium triacetoxyborohydride kuj tseem siv tau rau kev txo qis ntawm ob daim ntawv cog lus lossis triple-bond compounds, xws li txo cov alkyne tebchaw rau alkenes, thiab cov alkenes txo qis yuav tsis raug txo ntxiv los ntawm nws. Nyob rau tib lub sijhawm, nyob rau hauv lub xub ntiag ntawm kev hloov pauv hlau catalysts, nws tuaj yeem hloov halogenated hydrocarbons rau hauv alkanes.