Crizotinib (CAS 877399-52-5)yog ib lub qhov ncauj me me -molecule tsom tshuaj. Nws zoo nkaus li dawb rau tawm -dawb crystalline hmoov nrog cov mis molecular ntawm C₂₁H₂₂Cl₂FN₅O. Nws muaj qhov melting point ntawm 210-214℃thiab yog me ntsis soluble hauv dej tab sis dissolves zoo nyob rau hauv cov organic solvents xws li dimethyl sulfoxide (DMSO). Nws cov qauv tshuaj tso cai rau nws tshwj xeeb khi rau qee cov proteins, ua rau nws muaj txiaj ntsig zoo hauv kev thaiv cov kab mob ntawm tes tsis zoo.
1. Kho Tsis yog-Small Cell Lung Cancer (NSCLC)
Crizotinib feem ntau yog siv los kho NSCLC, tshwj xeeb tshaj yog cov kab mob qog noj ntshav muaj qee yam kev hloov pauv caj ces. Nws lub hom phiaj thiab inhibits kev ua ntawm anaplastic lymphoma kinase (ALK), cov protein uas, thaum hloov pauv, tuaj yeem ua rau tsis muaj kev tswj hwm ntawm tes hauv NSCLC. Los ntawm thaiv ALK, nws txwv tsis pub cov qog nqaij hlav qog noj ntshav los ntawm kev sib npaug, ua rau cov qog loj hlob qeeb thiab txo cov qog uas twb muaj lawm. Nws tau pom zoo rau cov neeg mob uas muaj ALK-NSCLC zoo, txheeb xyuas los ntawm kev ntsuam xyuas caj ces.
2. Lwm yam ALK-Cov Kabmob Zoo
Tshaj NSCLC, nws kuj tseem siv los kho lwm yam ALK- cov qog nqaij hlav zoo, xws li anaplastic loj cell lymphoma (ALCL) hauv cov menyuam yaus thiab cov neeg laus. ALCL yog ib hom tsis tshua muaj uas tsis yog -Hodgkin lymphoma uas tau tsav los ntawm ALK kev hloov pauv. Crizotinib lub peev xwm los inhibit ALK pab tswj kev sib kis ntawm cov qog nqaij hlav cancer no, txhim kho cov txiaj ntsig ntawm tus neeg mob.
3. ROS1-Positive Cancers
Crizotinib muaj txiaj ntsig zoo hauv kev kho NSCLC nrog ROS1 gene rearrangements. ROS1 yog lwm cov protein uas, thaum txawv txav, txhawb kev loj hlob ntawm qog noj ntshav. Cov tshuaj khi rau ROS1, thaiv nws cov haujlwm thiab ua kom mob qog noj ntshav qeeb. Qhov no nthuav dav nws txoj kev siv rau cov neeg mob uas muaj cov kab mob ROS1-zoo, muab cov kev xaiv kho mob uas ib txwm siv tshuaj khomob yuav tsis zoo.
Peb xa tawm Crizotinib txhua xyoo puag ncig, tuaj yeem ua kom ntseeg tau tias cov khoom lag luam zoo lav rau cov neeg siv khoom.Peb muab Cov Ntawv Pov Thawj Ua Lag Luam, Cov Ntawv Teev Npe, Cov Nqi Xa Khoom, COA.Koj puas txaus siab rau cov khoom no? Thov xa cov lus nug, thiab peb yuav tiv tauj koj hauv 24 teev ua haujlwm los tham txog koj cov kev xav tau.
Tiv tauj peb rau ib qho kev tsocai
Vim li cas thiaj xaiv Gneebio?
Gneebio nrog ntau xyoo dhau los ntawm kev tshawb fawb, kev tsim khoom thiab kev lag luam ntawm cov tshuaj organic, yog ib qho ntawm cov neeg xa khoom ntawm cov khoom siv tshuaj hauv Henan, Suav teb.Tau ntau xyoo, peb tau cog lus rau kev lag luam tshuaj lom neeg ntawm intermediates, yas additives, dej kho tshuaj thiab fungicide, thiab tshuaj txhua hnub.
Peb cov khoom nrov muaj xws li Cov Khoom Siv Hluav Taws Xob (Polyisobutylene, Styrene Monomer, Propylene Glycol, Cyclohexanone, Cyclohexane, Isopropyl Cawv), Cov Tshuaj Txhua Hnub (Didecylmethylamine, Dodecyl dimethyl betaine), thiab ntau yam Petrochemicals (Ethylene Tar, Petroleum).
Qhov zoo
1). Cov khoom xa tuaj me me thiab sub- ntim yog muaj.
2). Muab COA, MSDS, Daim Ntawv Pov Thawj Kev Noj Qab Haus Huv thiab Daim Ntawv Pov Thawj Keeb Kwm.
3). Ua ntej, kev pabcuam zoo tshaj plaws.
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