Curculigo orchioides yog siv rau kev kho mob ntawm impotence, limpness, mob caj dab ntawm lub lumbar thiab lub hauv caug pob qij txha, thiab dej raws plab nyob rau hauv cov tshuaj suav tshuaj, thiab kuj siv raws li ib tug muaj zog immunomodulator thiab aphrodisiac nyob rau hauv lub Ayurvedic kev kho mob system.
Curculigoside yog lub ntsiab saponin nyob rau hauv C. orchioide, exerts tseem ceeb antioxidant, tiv thaiv -osteoporosis, antidepressant thiab neuroprotection cuam tshuam.Curculigoside B, ib tug phenolic glycoside cais los ntawm Curculigo orchioide, txhim kho osteoblast proliferation, txo qhov chaw ntawm cov pob txha resorption. Antiosteoporotic thiab antioxidative kev ua ub no.
Osteoporosis yog ib qho teeb meem tshwm sim hauv cov neeg laus thoob ntiaj teb. Osteoporosis thiab fat build-up cuam tshuam rau kev kho pob txha. Raws li cov neeg muaj hnub nyoog, osteoporosis dhau los ua teeb meem loj dua. Cov tshuaj tiv thaiv tshiab -cov tshuaj tiv thaiv kab mob osteoporosis tsom ntawm osteoblasts tuaj yeem pab tsim cov pob txha thiab tiv thaiv cov rog. Suav tshuaj ntsuab yog siv los kho osteoporosis thiab pob txha pob txha. Curculigo orchioides yog siv ntau heev los kho osteoporosis senile. Nws yeej tsis tau tshaj tawm li cas CCG, ib qho tseem ceeb ntawm cov khoom siv bioactive ntawm Curculigo orchioides, cuam tshuam rau kev hloov ntawm adipocytes rau hauv osteoblasts hauv cov nas laus.
Cov txiaj ntsig: Curculigo orchioides, Curculigo capitulata thiab Curculigo pilosa tau siv los ua cov tshuaj ib txwm siv los kho cov kab mob xws li impotence, limpness, gastrointestinal thiab mob plawv, thiab lwm yam.
Curculigoside (CUR) yog ib qho phenolic glycoside tivthaiv ntawm Curculigo orchioides Gaertn uas nthuav tawm ntau yam tshuaj ua haujlwm, xws li tshuaj tiv thaiv -oxidant, tiv thaiv- mob thiab tiv thaiv - osteoporotic muaj peev xwm. Hauv cov kab mob neurological, CUR tau tshaj tawm los tiv thaiv neuronal excitoxicity, nco tsis ua haujlwm thiab kev nyuaj siab. Tsis tas li ntawd, cov kev tshawb fawb yav dhau los qhia tau hais tias CUR tiv thaiv hydrogen peroxide (H2O2) -induced osteoblast impairment los ntawm attenuating oxidative puas. Qhov tseem ceeb, Zhang et al. qhia tias CUR ua kom cov hlau ntau dhau- ua rau cov pob txha poob thiab oxidative kev nyuaj siab los ntawm kev txo qis ROS tiam thiab ua rau muaj kev tiv thaiv oxidant enzyme, xws li SOD thiab GPX , uas qhia txog nws txoj kev koom tes nrog ferroptosis.
Curculigoside cais los ntawm Curculigo orchioides tiv thaiv hydrogen peroxide -induced dysfunction thiab oxidative puas nyob rau hauv calvarial osteoblasts.
Curculigoside tau txais txiaj ntsig tseem ceeb los tiv thaiv kev mob caj dab hauv vivo thiab hauv vitro los ntawm kev tswj hwm ntawm JAK / STAT / NF-κB txoj kev taw qhia.
Raws li cov txiaj ntsig no, CUR muaj peev xwm tiag tiag los ua cov peev txheej tshiab rau kev tsim cov tshuaj lossis cov khoom noj khoom haus rau kev tiv thaiv thiab kev kho mob ntawm ob qhov sib txuas sib txuas nrog ntau yam kab mob kev loj hlob degenerative, AD thiab osteoporosis.