Khoom Description
Kev tshawb fawb hauv vitro ntawm VcMMAEa:
Monomethyl auristatin E (MMAE) tau tso tawm tau zoo los ntawm SGN-35 hauv CD30 + cov qog nqaij hlav cancer thiab, vim nws cov membrane permeability, muaj peev xwm ua kom muaj zog cytotoxic ntawm cov hlwb los ntawm cov neeg. MMAE rhiab heev rau cov qog nqaij hlav qog nqaij hlav hauv plab thiab pancreatic rau IR nyob rau hauv ib lub sij hawm thiab koob tshuaj raws li kev sib raug zoo nrog mitotic ntes. Radiosensitization yog pov thawj los ntawm kev txo qis clonogenic ciaj sia thiab nce DNA ob txoj hlua tawg hauv cov hlwb irradiated.
Hauv vivo txoj kev tshawb fawb ntawm VcMMAEa:
Monomethyl auristatin E (MMAE) ua ke nrog IR ua rau cov qog loj hlob qeeb, qog-targeted ACPP-cRGD-MMAE nrog IR ua rau lub cev muaj zog dua thiab ua rau lub sijhawm ntev ntawm cov qog regression hauv xenograft qauv.
Cov ntaub ntawv yooj yim
|
Yam khoom |
SPECIFICATION |
| CAS | 646502-53-6 |
|
Tshuaj Formula |
C68H105N11O15 |
|
Molecular Mass |
1316.63 |
|
Qhov ntom |
1.196 ± 0.06 g/cm3 (Tshaj tawm) |
|
Boiling Point |
1347.6 ± 65. 0 degree (Predicted) |
|
Solubility |
DMSO: Ntau dua lossis sib npaug ntawm 54 mg / mL |
|
Acidity Coefficient |
13.29 ± 0.70 (Tshaj tawm) |
|
Kev cia khoom |
Muab kaw rau hauv qhuav, Chav Kub |
Cov ntaub ntawv siv & kev ruaj ntseg
Nws txoj haujlwm tseem ceeb yog txhawm rau txo cov roj cholesterol hauv cov ntshav, yog li tiv thaiv thiab kho cov roj cholesterol siab thiab hyperlipidemia. Nws txo cov roj cholesterol hauv cov ntshav los ntawm inhibiting HMG-CoA reductase, cov roj cholesterol synthesizing enzyme, txo cov roj cholesterol synthesis, ua rau kev nthuav tawm ntawm cov lipoprotein tsawg-density lipoprotein (LDL) receptors, thiab txhawb LDL clearance.
Cov txheej txheem synthesis ntawm monomethyl auristatin E yog qhov nyuaj thiab muaj cov kauj ruam hauv qab no:
Ib qho nruab nrab yog tau los ntawm chemically reacting acetone cyanate nrog n-tert-butyl txhuas chloride.
Tom qab ntawd, qhov nruab nrab no tau tshwm sim nrog cov tshuaj reagents thiab cov organic tshuaj maj mam ua kom cov txheej txheem pob txha ntawm monomethyl oretastatin E.
Thaum lub sij hawm synthesis ntawm lub cev pob txha, ib tug series ntawm kev tiv thaiv thiab deprotection cov tshuaj tiv thaiv kuj yuav tsum tau los tiv thaiv thiab deprotect tej functional pawg.
Tom qab cov txheej txheem ua kom huv thiab ua kom huv, cov khoom kawg monomethyl orestatin E tau txais.
Cov txheej txheem synthesis yog tsim los siv rau kev tshawb fawb thiab kev kawm nkaus xwb, thiab tsis yog siv rau kev tsim lossis muag.
Tuam txhab Profile
Gnee Chemical Co., Ltd. tau tsim muaj nyob rau hauv 2014, npog thaj tsam ntawm 8 lab square meters, nrog rau tag nrho cov peev ntawm 5 lab RMB. Gnee Chemical Co., Ltd. yog lub tuam txhab high-tech integrating R&D, ntau lawm thiab muag khoom. Peb tab tom tos ntsoov yuav koom tes nrog cov phooj ywg los ntawm txhua qhov chaw ntawm lub neej rau lub neej yav tom ntej tshiab.
FAQ
Koj lub tuam txhab puas tuaj yeem lees txais cov neeg siv khoom tshwj xeeb?
Tseeb.
Kuv puas tuaj yeem tau txais qee cov qauv ua ntej muab xaj?
Yog lawm, peb zoo siab los muab cov qauv ua ntej tso qhov kev txiav txim, kom paub meej ntxiv, thov hu rau peb cov neeg ua haujlwm muag khoom.
Yuav ua li cas txog lub sij hawm xa khoom
Lub sij hawm xa tuaj: Cov khoom lag luam yuav raug xa tawm tam sim tom qab tau txais cov neeg siv khoom them nyiaj. Tab sis cov khoom customized yog nyob rau hauv muaj.
Kuv tuaj yeem lees paub qhov zoo ntawm cov khoom ua ntej qhov kev txiav txim?
Peb tuaj yeem xa koj cov qauv rau kev kuaj, lossis koj tuaj yeem xa peb cov khoom specifications thiab cov kev xav tau, thiab peb yuav tsim cov khoom raws li koj xav tau.
Koj puas muab cov khoom qhia?
Yog lawm. Peb yuav muab cov ntaub ntawv txheeb xyuas cov khoom rau koj ua ntej ua zaub mov xa tuaj.
Cim npe nrov: cas no.646502-53-6 vcmmae, Tuam Tshoj cas no.646502-53-6 vcmmae manufacturers, lwm tus neeg, Hoobkas
