Dab tsi yogN-Acetyl-D-mannosamine (ManNAc)?
N-Acetyl-D-mannosamine (ManNAc)yog ib qho kev hais lus ntawm sialic acid precursor uas tiv thaiv kev kub siab los ntawm kev nce sialylation ntawm IgG, uas tau cog lus rau kev tshawb fawb kab mob plawv.N-Acetyl-D-mannosamineactivates hypocretin (HCRT) noob qhia nyob rau hauv orexigenic neurons thiab ameliorates aging-induced paj hlwb puas, muaj peev xwm rau kev tshawb fawb kab mob neurological.N-Acetyl-D-mannosaminetuaj yeem qhib hypocretin (HCRT) gene qhia hauv orexigenic neurons thiab ameliorate aging-induced neurological puas, uas muaj peev xwm rau kev tshawb fawb txog cov kab mob neurological.
Vim li cas cov neeg rog rog feem ntau ua rau ntshav siab?
Cov lus teb tuaj yeem yooj yim li qhov poob ntawm cov piam thaj molecule, raws li kev tshawb fawb UT Southwestern tsis ntev los no.
"Raws li peb cov txiaj ntsig, nws yuav muaj peev xwm noj tshuaj ntxiv los tiv thaiv kev rog los ntawm kev ua kom ntshav siab," said Dr. Philip Shaul, xibfwb thiab Tus Lwm Thawj Coj ntawm Kev Tshawb Fawb hauv Department of Pediatrics ntawm UT Southwestern thiab co-senior sau ntawm ib txoj kev kawm tshiab Circulation. "Thaum peb muab cov khoom siv los ua cov suab thaj no rau cov nas, nas tau tiv thaiv los ntawm kev mob ntshav siab - txawm tias lawv rog."
Kev sib raug zoo ntawmN-Acetyl-D-mannosaminethiab rog:
Hu ua ManNac, luv rauN-acetyl-D-mannosamine, qhov no tshwm sim ib txwm muaj nyob rau hauv lub cev thaum lub sij hawm tsim cov suab thaj hu ua sialic acid. Sialic acid yog ib qho tseem ceeb ntawm cov kab sib txuas ntawm cov suab thaj uas muaj nyob ntawm immunoglobulin (IgG), cov txheej txheem los ntawm cov tshuaj tiv thaiv. Txoj kev tshawb no qhia tias qib ntawm sialic acid ntawm IgG qab zib saw poob hauv tib neeg thiab nas thaum rog rog nce.
Hauv tib neeg, raws li qib ntawm IgG-txuas sialic acid poob qis, cov ntshav siab nce mus rau hauv teeter-totter zam, raws li kev tshawb pom hauv ntau dua 3,400 tus neeg koom nrog sim, Dr. Shaul tau hais.
Hauv cov nas, ntxiv ManNac rau lawv cov dej haus tau hloov cov sialic acid ntawm IgG qab zib saw thiab tiv thaiv ntshav siab, txoj kev tshawb no qhia.
Daim ntawv thov ntawmN-Acetyl-D-mannosamine:
1. Kev tshawb fawb txog kev lom neeg: N-Acetyl-D-mannosamine feem ntau yog siv rau hauv kev tshawb fawb ntawm glycobiology thiab biochemistry. Nws tuaj yeem siv los ua ib qho substrate rau enzyme-catalyzed cov tshuaj tiv thaiv, ua cov tshuaj lom neeg lom neeg rau kev kawm ntawm cov cell nto molecules, thiab ua cov khoom sib xyaw ua ke rau kev sib txuas thiab hloov kho ntawm glycoproteins.
2. Kev npaj cov tshuaj thiab cov khoom siv roj ntsha: N-Acetyl-D-mannosamine yog ib qho tseem ceeb nruab nrab ntawm cov tshuaj synthesis, uas tuaj yeem siv los ua cov tshuaj tiv thaiv kab mob, immunomodulators, cov khoom siv roj ntsha thiab tshuaj tiv thaiv. Piv txwv li, N-Acetyl-D-mannosamine tuaj yeem siv los npaj glycogen rau tshuaj tiv thaiv kab mob khaub thuas A.
3. Kev lag luam zaub mov: N-Acetyl-D-mannosamine kuj tuaj yeem siv rau hauv kev lag luam khoom noj. Nws tuaj yeem siv los txhim kho qhov saj thiab kev ntxhib los mos ntawm cov khoom noj, xws li nce viscosity ntawm cov khoom noj siv mis thiab nqaij, ua kom cov khoom noj muaj fiber ntau thiab lwm yam.
4. Tshuaj pleev ib ce: N-Acetyl-D-mannosamine kuj siv rau hauv tshuaj pleev ib ce. Nws tuaj yeem siv los ua moisturizer thiab tiv thaiv kev laus, uas yuav pab kom moisturize thiab txhim kho kev ntxhib los mos thiab elasticity ntawm daim tawv nqaij.
5. Lwm yam kev siv: N-Acetyl-D-mannosamine kuj tuaj yeem siv rau hauv kev npaj cov ntaub ntawv, tshuaj thiab biofuels.
Zuag qhia tag nrho, N-Acetyl-D-mannosamine muaj ntau yam ntawm daim ntawv thov kev cia siab thiab kev ua lag luam muaj peev xwm, thiab tseem ceeb heev rau kev ua haujlwm ntawm glycochemistry, biologics thiab life sciences.