Txoj kev tshawb nrhiav no suav nrog xya tus neeg laus uas muaj tus kab mob Parkinson, uas tau muab 500 mg ntawm tributyrin peb zaug hauv ib hnub rau 30 hnub.
Nyob rau ntawm International Association of Parkinsonism thiab Related Disorders World Congress, cov ntaub ntawv nthuav tawm qhia tias tributyrin supplementation yuav muaj txiaj ntsig zoo rau cov tsos mob ntawm lub cev thiab cov cim inflammatory hauv Parkinson tus kab mob.
Tributyrin yog ib tug dawb, yuav luag oily kua nrog ib tug ntxhiab tsw, me ntsis roj aroma. Nws yog dawb do soluble nyob rau hauv ethanol, chloroform, thiab ether, thiab nyuaj heev rau yaj nyob rau hauv dej (0.010%). Natural khoom muaj nyob rau hauv siab.
Nyob rau hauv qhov pom ntawm cov pov thawj tshwm sim qhia tias plab- lub hlwb axis tsis ua hauj lwm yuav ua rau lub pathophysiology ntawm Parkinson's disease (PD), Griggs thiab cov npoj yaig nrhiav kev tshawb fawb txog qhov muaj feem cuam tshuam ntawm tributyrin supplementation (triglyceride ntawm butyric acid) ntawm cov qauv pw tsaug zog, cov tsos mob ntawm tus neeg mob PD.
Txoj kev tshawb fawb theem 1b suav nrog xya tus neeg laus cov neeg koom nrog kuaj mob PD (lub hnub nyoog nruab nrab, 65.6 xyoo) uas tau txais lub hauv paus lub cev muaj zog thiab kev ntsuam xyuas kev txawj ntse, taug qab kev pw tsaug zog, thiab kev kuaj ntshav sai. Cov neeg koom nrog tau muab 500 mg ntawm tributyrin peb zaug hauv ib hnub rau 30 hnub. Tom qab qhov no, lawv yuav tsum tau rov qab mus rau kev kuaj mob thiab kev kuaj mob.
Cov kws tshawb fawb tau soj ntsuam cov txiaj ntsig tseem ceeb, suav nrog qhov mob hnyav ntawm lub cev muaj zog raws li ntsuas los ntawm Unified Parkinson's Disease Rating Scale-III (UPDRS-III) tag nrho cov qhab nia, cov kab mob hauv lub cev los ntawm siab -rhiab heev C-reactive protein (hs-CRP) ntawm peb lub plawv variation.
Tributyrin tau pom tias yog ib qho kev kho mob zoo rau cov tib neeg uas muaj tus kab mob Parkinson, nrog rau lawv cov qauv kev saib xyuas. Nws cov thawj coj tau pom tias muaj txiaj ntsig zoo rau cov tsos mob ntawm lub cev muaj zog, txhim kho qhov profile ntawm cov kab mob inflammatory, thiab txhim kho lub plawv dhia nocturnal variability.
Cov cim inflammatory hauv qab no suav nrog: tag nrho cov qe ntshav dawb suav, C-reactive protein, calcitonin, erythrocyte sedimentation tus nqi ntsuas, thiab platelet suav.
Tributyrin siv nws cov tshuaj tiv thaiv - mob thiab kev tiv thaiv kab mob los ntawm kev hloov kho qhov qhia tawm ntawm kev tiv thaiv - cov kab mob inflammatory thiab tswj T hlwb (Tregs), thaum tseem txhim kho lub peev xwm antioxidant. Glyceryl tributyrate tau pom zoo los txhim kho kev tiv thaiv kab mob hauv cov tsiaj txhu ntawm ntau txoj hauv kev. Nws boosts tsiaj tiv thaiv los ntawm boosting lub cev tiv thaiv kab mob, nce tus naj npawb ntawm Tregs, txo o, thiab nce antioxidants.