Txoj kev tshawb nrhiav no suav nrog xya tus neeg laus uas muaj tus kab mob Parkinson, uas tau muab 500 mg ntawm tributyrin peb zaug hauv ib hnub rau 30 hnub.
Ntawm lub koom haum International Association of Parkinsonism thiab Related Disorders World Congress, cov ntaub ntawv nthuav tawm qhia tias kev noj tshuaj tributyrin tuaj yeem muaj txiaj ntsig zoo rau cov tsos mob ntawm lub cev thiab cov cim inflammatory hauv Parkinson tus kab mob.
Tributyrin yog ib tug dawb, yuav luag oily kua nrog ib tug ntxhiab tsw, me ntsis roj aroma. Nws yog dawb do soluble nyob rau hauv ethanol, chloroform, thiab ether, thiab nyuaj heev rau yaj nyob rau hauv dej (0.010%). Natural khoom muaj nyob rau hauv siab.
Nyob rau hauv lub teeb ntawm cov pov thawj tshwm sim qhia tau hais tias lub plab-hlwb axis tsis ua hauj lwm tej zaum yuav ua rau lub pathophysiology ntawm Parkinson tus kab mob (PD), Griggs thiab cov npoj yaig nrhiav los soj ntsuam qhov muaj feem cuam tshuam ntawm tributyrin supplementation (a triglyceride ntawm butyric acid) ntawm kev pw tsaug zog, cov tsos mob ntawm lub cev muaj zog. , thiab inflammatory blood markers nyob rau hauv cov neeg uas muaj PD.
Txoj kev tshawb fawb theem 1b suav nrog xya tus neeg laus cov neeg koom nrog kuaj mob PD (lub hnub nyoog nruab nrab, 65.6 xyoo) uas tau txais lub hauv paus lub cev muaj zog thiab kev ntsuam xyuas kev txawj ntse, taug qab kev pw tsaug zog, thiab kev kuaj ntshav sai. Cov neeg koom nrog tau muab 500 mg ntawm tributyrin peb zaug hauv ib hnub rau 30 hnub. Tom qab qhov no, lawv yuav tsum tau rov qab mus rau kev kuaj mob thiab kev kuaj mob.
Cov kws tshawb fawb tau soj ntsuam cov txiaj ntsig tseem ceeb, suav nrog qhov mob hnyav ntawm lub cev muaj zog raws li ntsuas los ntawm Unified Parkinson's Disease Rating Scale-III (UPDRS-III) tag nrho cov qhab nia, cov kab mob hauv lub cev los ntawm kev kub siab C-reactive protein (hs-CRP), thiab variability ntawm nocturnal lub plawv dhia siv lub nplhaib Oura.
Tributyrin tau pom tias yog ib qho kev kho mob zoo rau cov tib neeg uas muaj tus kab mob Parkinson, nrog rau lawv cov qauv kev saib xyuas. Nws cov thawj coj tau pom tias muaj txiaj ntsig zoo rau cov tsos mob ntawm lub cev muaj zog, txhim kho qhov profile ntawm cov kab mob inflammatory, thiab txhim kho lub plawv dhia nocturnal variability.
Cov kab mob hauv qab no suav nrog: tag nrho cov qe ntshav dawb suav, C-reactive protein, calcitonin, erythrocyte sedimentation tus nqi ntsuas, thiab platelet suav.
Tributyrin exerts nws anti-inflammatory thiab immunomodulatory teebmeem los ntawm modulating cov kev qhia ntawm anti-inflammatory yam tseem ceeb thiab kev tswj T hlwb (Tregs), thaum tseem pab tau antioxidant muaj peev xwm. Glyceryl tributyrate tau pom zoo los txhim kho kev tiv thaiv kab mob hauv cov tsiaj txhu ntawm ntau txoj hauv kev. Nws boosts tsiaj tiv thaiv los ntawm boosting lub cev tiv thaiv kab mob, nce tus naj npawb ntawm Tregs, txo o, thiab nce antioxidants.