Zerumbone yog ib qho organic compound feem ntau muab los ntawm cov rhizomes ntawm Zingiber zerumbet, feem ntau hu ua zawv plaub hau qhiav los yog pinecone qhiav. Qhov sib xyaw no yog tus cwj pwm los ntawm nws cov qauv tshuaj tshwj xeeb, uas suav nrog sesquiterpene moj khaum uas pab txhawb rau nws cov haujlwm lom neeg ntau yam.
Zerumbone's antioxidants kuj tseem pab tiv thaiv qhov muag muag tshaj plaws ntawm lub ntsej muag ntawm daim tawv nqaij los ntawm kev pom kev hloov pauv vim muaj kev cuam tshuam ib puag ncig. Nws tseem pab tiv thaiv daim tawv nqaij ntawm qhov chaw ntawm UVA hluav taws xob, cuam tshuam kev puas tsuaj ua ntej nws mus txog ntawm daim tawv nqaij qis. Cov nyiaj tau los ntawm {{0}}.03–0.2% suav tias yog siv tau.
Cov tawv nqaij hydration thiab anti-inflammatory muaj peev xwm ntawm zerumbone, ib tug natural sesquiterpene ntawm Zingiber zerumbet, enhanced Src/ERK-mediated HAS-2/AQP-3 thiab inhibited NFκB/AP-1 qhia hauv UVB - irradiated tib neeg keratinocytes.
Kev laus ntawm daim tawv nqaij yog tshwm sim los ntawm kev sib xyaw ntawm cov caj ces thiab ib puag ncig. Hnub ci muaj UV rays uas cuam tshuam rau ntawm daim tawv nqaij. Muaj peb hom UV teeb: A, B, lossis C. UVA (315-400 nm) yog cov khoom tseem ceeb uas muaj peev xwm nkag mus tau siab. Nws nkag mus tob rau hauv daim tawv nqaij thiab ua rau muaj kev ntxhov siab hauv cov hlwb ntawm daim tawv nqaij, uas ua rau cov cim qhia ntxov ntawm kev laus thiab kev puas tsuaj. Extrinsic tawv nqaij laus ua rau sagging, xoob ntawm daim tawv nqaij, patchy pigmentation, wrinkles, thiab dryness.
UVA rays tuaj yeem ua rau daim tawv nqaij puas los ntawm kev ua rau cov hlwb tuag. Qhov no tuaj yeem ua rau tawv nqaij laus thiab mob qog noj ntshav. Peb tau sim cov kev tiv thaiv ntawm zerumbone (ib yam tshuaj muaj nyob hauv Ginger) ntawm tib neeg cov tawv nqaij hlwb thiab cov tawv nqaij nas. Zerumbone pretreatment (2-10 μM) txo qis UVA (15 J / cm²)-vim HaCaT cell tuag thiab lactate dehydrogenase tso tawm. UVA-induced kev puas tsuaj rau cov hlwb tau thim rov qab los ntawm zerumbone. Zerumbone tiv thaiv cov hlwb los ntawm kev nce tus nqi ntawm Nrf2 hauv lub nucleus thiab los ntawm kev ua kom cov hlwb tiv thaiv kev puas tsuaj. Nrf2/ARE signaling tau qhib rau hauv zerumbone-kho keratinocytes, uas kuj ua rau HO-1 thiab -GCLC noob. Zerumbone qhib Nrf2 txog p38 MAPK, PI3K / AKT, thiab PKC. Silencing Nrf2 (siRNA transfection) txo qis zerumbone-mediated cytoprotective teebmeem. Qhov no tau ua pov thawj los ntawm cov noob caj noob ces tsis zoo, tsis tswj ROS / apoptotic DNA fragmentation, thiab keratinocyte tuag tom qab UVA irradiation. Zerumbone kev kho mob rau cov nas liab qab txo qis UVA cytotoxicity. Qhov no yog vim muaj zog nuclear localization ntawm Nrf2 thiab Nrf2-nyob ntawm cov tshuaj tiv thaiv antioxidant hauv cov ntaub so ntswg UVA. Peb qhov kev tshawb pom pom tias Nrf2/ARE-signaling tseem ceeb rau zerumbone los tiv thaiv UVA-toxicity. Cov pov thawj molecular qhia tau hais tias zerumbone tuaj yeem siv los ua cov tshuaj ntuj.