Alzheimer's disease (AD), ib qho kev puas siab puas ntsws loj heev, ua rau muaj kev cuam tshuam kev lag luam hauv zej zog thiab xav tau cov tswv yim kho mob tshiab. Cov kev pabcuam khomob tam sim no raug txwv thiab qhia txog qhov xav tau ntawm cov tshuaj tiv thaiv tshiab ntawm acetylcholinesterase (AChE) thiab butyrylcholinesterase (BChE), enzymes cuam tshuam rau hauv pathogenesis ntawm AD.
Aminopyridine yog ib qho organic compound nrog cov mis H2NC5H4N. Nws yog ib qho ntawm peb isomeric aminopyridines. Nws yog cov khoom tsis muaj xim uas siv los tsim cov tshuaj piroxicam, sulfapyridine, tenoxicam, thiab tripelennamine.
Alzheimer's disease (AD) yog ib qho kev mob loj heev uas feem ntau cuam tshuam rau cov tib neeg muaj hnub nyoog 65 xyoos, txawm tias qhov pib ntxov tuaj yeem tshwm sim thaum muaj hnub nyoog qis dua. Thaum pib, AD cuam tshuam rau qhov chaw ntawm lub hlwb uas tswj kev nco, kev xav, thiab kev txawj hais lus, thiab thaum tus kab mob loj tuaj, cov tib neeg yuav ntsib kev tsis meej pem, kev hloov tus cwj pwm, tsis muaj peev xwm ua txhua hnub, tsis hais lus, thiab kev sib raug zoo.
2-aminopyridines yog ib pab pawg tseem ceeb ntawm nitrogen heterocyclic compounds thiab feem ntau pom tias yog cov txheej txheem tseem ceeb hauv cov khoom siv roj ntsha. Cov hom kev sib txuas no feem ntau pom muaj nyob rau hauv ntau yam sib xyaw ua ke, xws li cov khoom siv fluorescent organic thiab kev kho mob. Ntau txoj hauv kev tau tsim los tsom rau cov heterocycles no, suav nrog cov tshuaj tiv thaiv amination, Chichibabin aromatic hloov pauv 16, kev hloov pauv ntau yam, thiab hetero Diels-Alder cov tshuaj tiv thaiv. Cov tebchaw sib txawv no nthuav tawm ntau yam kev ua haujlwm lom neeg, suav nrog inhibition ntawm nitric oxide synthases (NOS). Lawv tuaj yeem siv los ua cov neeg nruab nrab hauv kev tsim cov tshuaj, xws li piroxicam. Lawv kuj muaj peev xwm chelating thiab siv li ligands hauv ob qho tib si organic thiab inorganic chemistry. Ntawm cov derivatives ntawm 2-aminopyridine, aryl-substituted derivatives nthuav tawm ntau yam kev lom zem, xws li allosteric BCRABL1 inhibitor, kev kho mob neurodegeneration, anticancer, kev kho mob ntawm cov kab mob fungal.
Hauv kev xaus, peb tau tsim cov txheej txheem rau qhov yooj yim synthesis ntawm ntau yam uas muaj peev xwm ua kom lom neeg lom zem aryl-hloov pauv 2-aminopyridine los ntawm cov tshuaj tiv thaiv cascade. Cov tshuaj tiv thaiv no muab txoj hauv kev tshiab, sai, thiab muaj txiaj ntsig zoo rau kev npaj ntau yam ntawm aryl-hloov pauv 2-aminopyridine hauv qhov zoo rau cov txiaj ntsig zoo los ntawm cov khoom tsim tau yooj yim ntawm aryl vinamidinium ntsev 1 thiab EDAms 2.